Carlos Alcaraz dismantled Reilly Opelka in straight sets to reach the second round.
Sinner remains the man to beat at Melbourne Park even as doping officials seek a two-year ban for the world number one for failing two drugs tests last March.
13 of the men's seeds fell at the first hurdle -- a Wimbledon record since 32 seeds were introduced in 2001.
'And to all those people that have chosen to disrespect the player, in this case me, have a goooooood night!'
Sinner faces defending champ Alcaraz in hotly anticipated French Open final
Alcaraz has not gone beyond the quarter-finals in his three previous visits to Melbourne, but that has not stopped the world number three from dreaming of glory in the Jan. 12-26 event.
Britain's Cameron Norrie stunned world number one Carlos Alcaraz to reach the third round of the Paris Masters.
'I've done an incredible job with my fitness. I've done an incredible job with my physiotherapy, so I've maximized on everything that I possibly can do.'
Former Team India skipper and accomplished batter Ajinkya Rahane made a surprise appearance at Wimbledon 2025 with the Thursday fixtures lining up third round matches of men's World No. 1 Jannik Sinner and five-time Grand Slam champion Iga Swiatek.
Seven-times champion Novak Djokovic produced some of his best tennis to outclass Italian 25th seed Lorenzo Musetti 6-4, 7-6(2), 6-4 on Friday and reach a 10th Wimbledon final on Friday.
Factbox on Italy's Jannik Sinner, who beat Germany's Alexander Zverev 6-3, 7-6(4), 6-3 in the Australian Open final
Japan Open: Alcaraz marches into quarterfinals, hails "best physio in the world" after overcoming ankle issues
World Champion D Gukesh's quest for a victory continued as Hikaru Nakamura defeated him in the tie-breaker of the 5-8 place play-off at the Freestyle Chess Grand Slam.
Gael Monfils thrilled the Roland Garros crowd with his 12th five-set victory at the French Open on Tuesday before revealing that he does not enjoy having to dig himself out of deep holes at Grand Slams.
Defiant Djokovic still targeting Grand Slam wins after Australia setback
Novak Djokovic won a record-equalling 20th Grand Slam title by after winning this year's Wimbledon drawing level with long-time rivals Roger Federer and Rafael Nadal.
Carlos Alcaraz heads to the US Open in his now-familiar role as chief challenger to defending champion Jannik Sinner and the Spaniard will be driven this year by the twin pursuit of Grand Slam glory and the World No. 1 ranking.
Rangy 19-year-old Mensik, the 2022 boy's singles finalist at Melbourne Park, sealed the match in style with a searing forehand winner to push the three-times Grand Slam finalist and sixth seed to the exit.
India's N Sriram Balaji and his Mexican partner Miguel Reyes-Varela's French Open journey came to an end with the second round defeat against fourth seed Italians Simone Bolelli and Andrea Vavassori, in Paris on Saturday.
Here is what you need to know about the prize pot on offer at Wimbledon 2025, the third major of the year:
Aryna Sabalenka is the red-hot favourite at Melbourne Park, where another victory would give her a fourth major title and widen the gap in the rankings to Poland's Iga Swiatek and Coco Gauff of the United States.
After a gutsy performance that pushed Sinner to four sets, the Italian world number one ultimately proved too strong. Yet the Canadian said he would carry plenty of positives forward from Flushing Meadows.
As the spotlight shines on Carlos Alcaraz's title defence and Novak Djokovic's pursuit of a record 25th Grand Slam, a determined group of challengers is quietly preparing to shake up the draw.
Rafael Nadal says he will decide when to retire following the Paris Olympics after losing in straight sets to 24-times Grand Slam winner Novak Djokovic in the second round of the singles.
Third seed Iga Swiatek will play against Italy's Jasmine Paolini in her first Cincinnati Open final.
Italian Cocciaretto stuns Pegula in big Wimbledon upset; Olympic champion Zheng Qinwen was beaten by Czech Katerina Siniakova.
Andy Murray will no longer coach 24-time Grand Slam champion Novak Djokovic, with the pair's high-profile partnership coming to an end after six months and no titles, the Briton's team said on Tuesday.
Venus Williams has received a wild card main draw entry into the Cincinnati Open, as the 45-year-old American enjoys an age-defying return to the spotlight.
Wimbledon sprang into life on Monday as the world's oldest tennis tournament opened its gates to thousands of spectators who had queued up for hours in the gentle morning sunshine.
Jannik Sinner begins his Australian Open title defence against Nicolas Jarry while women's champion Aryna Sabalenka takes on 2017 U.S. Open winner Sloane Stephens
Emma Raducanu strides onto the grasscourts of Wimbledon on Monday as the British number one
Senior pros Rohit Sharma and Virat Kohli made a grand comeback to the Vijay Hazare Trophy, smashing centuries on the opening day of the one-day tournament on Wednesday.
The Russian, 28, whacked his racket into the net five times as his frustration boiled over during his opening victory against Thai wildcard Kasidit Samrej on Tuesday.
Aryna Sabalenka and Coco Gauff resume their simmering rivalry on the pristine lawns of London.
World champion GM D Gukesh finished tied sixth as Levon Aronian of USA convincingly won the St. Louis Rapid and Blitz that concluded in St Louis.
Carlos Alcaraz said he could hold his head high despite being unseated from his Wimbledon throne by Jannik Sinner on Sunday and the Spaniard praised their hot rivalry for being several notches higher than the others on the men's tour.
Sabalenka relied on her trademark powerful serve to hold firm in the key moments, winning two tiebreaks to take her tally to 18 for the season, the most by any women's singles player in the professional era.
The Polish eighth seed walloped Liudmila Samsonova 6-2, 7-5 to reach the Wimbledon semi-finals for the first time.
Madison Keys, 29, is the fourth-oldest first-time Grand Slam champion in the professional era.
Sabalenka, who has never reached the final at Roland Garros, believes she is now better equipped both physically and mentally to challenge on clay, a surface she concedes took her years to master.
